| Date | Opponent* | Result | | |
| Sept. 5, 2009 | at Arizona | 10:00 pm ET | | |
| Sept. 12, 2009 | at Michigan State | 12:00 pm ET | | |
| Sept. 19, 2009 | Alcorn St. | TBA | | |
| Sept. 26, 2009 | Akron | 3:30 pm ET | | |
| Oct. 3, 2009 | at Buffalo | 3:30 pm ET | | |
| Oct. 10, 2009 | Eastern Michigan | TBA | | |
| Oct. 17, 2009 | at Western Michigan | TBA | | |
| Oct. 24, 2009 | at Bowling Green | TBA | | |
| Oct. 31, 2009 | at Boston College | TBA | | |
| Nov. 11, 2009 | Toledo | 8:00 pm ET | | |
| Nov. 18, 2009 | at Ball State | TBA | | |
| Nov. 27, 2009 | Northern Illinois | TBA |
B&G: Scott Warheit- Tigers CutOff Man Blog
HUGE: Joe Rexrode-LSJ.com-MSU Football Insider
HUGE: Jim Brandstatter-U-M color analyst
HUGE: Chris Balas-thewolverine.com
B&G: Sean Leahy-NFL Writer-USA Today
